Ebola virus disease: current vaccine solutions

Ebola Virus Disease (EVD) is a promising zoonotic disease with sporadic outbreaks in Central and West African countries. It has unpredictable high case fatality rate and public health concern. From 2013-2016, in West Africa, a licensed vaccine was used as prophylactic protection in human and non-human primates, and also showed progress rate against to the devastating outbreak of EVD. Recently, two vaccines: Ervebo (rVSV-ZEBOV) and a two-dose combination of Zabdeno (Ad26.ZEBOV) and Mvabea (MVA-BN-Filo) have been authorized and in use. Many reasons are making challenge the licensing of an Ebola vaccine such as the sporadic and limited nature of EVD outbreaks and shortage of resources needed to bring a vaccine to licensure. For reducing the fatality of EVD, not only vaccine solutions are still important but also other strategic interventions are necessary for the prevention and control of EVD.

(RA)